Key result
CASQ1-null mice exhibited increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death, characterized by whole-body contractures and severe rhabdomyolysis.
Population
Calsequestrin-1 (CASQ1)-knockout mice
Design
Preclinical
Authors
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Positions CASQ1 as candidate gene for malignant hyperthermia; leaves open human translation and clinical relevance.
CASQ1 deficiency in mice leads to increased susceptibility to heat- and anesthetic-induced sudden death, suggesting CASQ1 as a candidate gene for malignant hyperthermia and environmental heat stroke.
Dainese et al. (2009) studied Malignant hyperthermia and environmental heat stroke models. CASQ1 deficiency and exposure to 2% halothane or heat stress vs. Wild-type mice (implied) was evaluated on Spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death. CASQ1-null mice exhibited increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death, characterized by whole-body contractures and severe rhabdomyolysis.
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