Why the study?
Does the in vitro ryanodine contracture test at 1 or 2 microM accurately distinguish malignant hyperthermia susceptible patients from normal patients?
Population
109 patients providing skeletal muscle specimens.
Comparison
In vitro ryanodine contracture test using… vs Comparison between patient groups and between…
Design
Other
Authors
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Supports 1 μM ryanodine contracture testing for accurate MH diagnosis; confirms complete separation of MHS and MHN responses in RCT evidence.
Does the in vitro ryanodine contracture test at 1 or 2 microM accurately distinguish malignant hyperthermia susceptible patients from normal patients?
The in vitro ryanodine contracture test using 1 microM ryanodine effectively distinguishes malignant hyperthermia susceptible patients from normal patients without overlap.
Wappler et al. (1996) studied this question.
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