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February 1, 1993Journal of Medical GeneticsOpen Access

The genetics of malignant hyperthermia.

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Population

Families and patients with malignant hyperthermia susceptibility

Design

Review

Authors

SBSarah BallKJKeith Johnson

Discussion

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Overview

Restricts presymptomatic DNA testing for malignant hyperthermia to linked families; leaves open broader gene discovery.

Structured PICO

P
Population
Families and patients with malignant hyperthermia susceptibility
I
Intervention
Presymptomatic testing based on DNA markers (linkage to chromosome 19q13.1-13.2)

Genetic heterogeneity limits presymptomatic DNA testing for malignant hyperthermia to families with proven linkage to chromosome 19q13.1-13.2.

Cite This Study

Ball et al. (1993) studied this question.

synapsesocial.com/papers/6a703e2b6c240de38cdbbac0https://doi.org/10.1136/jmg.30.2.89
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetics and pathogenesis of malignant hyperthermia2000 · 297 citations
  2. 2The anesthetic myopathies and malignant hyperthermias1998 · 32 citations
  3. 3A proposed North American approach for genetic testing of individuals at risk for malignant hyperthermia2026
  4. 4Genetics of Malignant Hyperthermia2006 · 36 citations
  5. 5Genetics of Malignant Hyperthermia2020 · 15 citations