Population
Patients susceptible to malignant hyperthermia
Design
Review
Key result
Mutant alleles at loci on chromosomes 1q, 3q, 5p, 7q, and 19q are believed to account for up to 50% of human malignant hyperthermia susceptibility.
Authors
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Genetic testing for MH susceptibility remains incomplete; leaves open identification of additional loci for comprehensive panels.
Molecular genetic techniques have identified multiple loci accounting for up to 50% of malignant hyperthermia susceptibility, highlighting significant genetic heterogeneity.
Kirk J. Hogan (1998) conducted a review in Malignant hyperthermia. Mutant alleles at loci on chromosomes 1q, 3q, 5p, 7q, and 19q are believed to account for up to 50% of human malignant hyperthermia susceptibility.