Why the study?
Atrial fibrillation is the most common sustained arrhythmia worldwide, but the relationship between AF and iron deficiency is poorly understood.
Iron deficiency is highly prevalent (60.4%) among patients with atrial fibrillation, particularly in females and those with higher comorbidity burdens.
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Iron deficiency affects >60% of AF patients by ACC criteria; leaves open whether screening or repletion improves outcomes.
Background and Objectives: Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. The relationship between AF and iron deficiency is poorly understood. Materials and Methods: We conducted an observational study investigating the prevalence of iron deficiency in those with AF. Iron deficiency was defined by the American College of Cardiology (ACC) criteria for iron deficiency in heart failure. Results: Of 134 eligible subjects, 81 (60.4%) met the ACC definition of iron deficiency in heart failure. Those who were iron deficient were more likely to be female (OR 1.876, p = 0.005), have a history of diabetes mellitus (OR 3.085, p = 0.001) a history of stroke (OR 3.147, p = 0.016), and have higher CHA2DS2-VASc (p ≤ 0.0001) and Charlson Comorbidity Index scores (CCI) (p = 0.007). Conclusions: The prevalence of iron deficiency in those with AF appears high and warrants evaluation in a prospective study.
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Alabdullah et al. (2022) studied this question.
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