Why the study?
Does oral magnesium l-lactate reduce the QTc interval in patients receiving sotalol or dofetilide for atrial or ventricular arrhythmias?
Population
Patients receiving sotalol or dofetilide for atrial or ventricular arrhythmias
Comparison
Magnesium l-lactate for 48 hours vs Placebo for 48 hours
Design
RCT, Randomized
Follow-up
51 hours
Authors
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Supports adjunctive oral magnesium to attenuate QTc prolongation with sotalol or dofetilide; extends RCT evidence for electrolyte repletion in arrhythmia patients.
Does oral magnesium l-lactate reduce the QTc interval in patients receiving sotalol or dofetilide for atrial or ventricular arrhythmias?
Oral magnesium l-lactate effectively reduces the QTc interval and raises intracellular magnesium in patients receiving sotalol or dofetilide, potentially mitigating proarrhythmic risk.
McBride et al. (2006) studied this question.
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