Why the study?
Does captopril or hydralazine improve hemodynamics and prevent left ventricular dilatation in rats with large myocardial infarctions?
Population
Rats subjected to coronary artery ligation with large myocardial infarctions selected by ECG criteria and a…
Comparison
Captopril or hydralazine administered for 4 weeks. vs Placebo administered for 4 weeks.
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports captopril hemodynamic effects in rat MI; hypothesis-generating for human postinfarct therapy.
Does captopril or hydralazine improve hemodynamics and prevent left ventricular dilatation in rats with large myocardial infarctions?
Captopril, a mixed arterial and venous vasodilator, improves hemodynamics and venous compliance in rats with large myocardial infarctions.
Raya et al. (1989) studied this question.
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