What question did this study set out to answer?

To evaluate longitudinal alterations in total vascular pressure-volume relations, vascular compliance, and cardiac output in DOCA-salt hypertensive rats.

July 1, 1983Hypertension

Circulatory pressure-volume relationship and cardiac output in DOCA-salt rats.

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Why the study?

Does DOCA-salt treatment alter the circulatory pressure-volume relationship and cardiac output in rats?

Population

Rats (conscious and anesthetized)

Comparison

DOCA-salt treatment vs Sham treatment

Design

Preclinical

Follow-up

8 weeks

Authors

JYJ. YamamotoHosei University YGYukari GotoNagoya Ekisaikai Hospital MNM. NakaiThe University of Osaka

Discussion

Member takes

Implication

Altered vascular capacity may preserve cardiac output against rising afterload in this rat model; leaves open relevance to human hypertension.

Key Points

To evaluate longitudinal alterations in total vascular pressure-volume relations, vascular compliance, and cardiac output in DOCA-salt hypertensive rats.
Assessed conscious DOCA-salt hypertensive and sham-treated control rats at 1, 2, 5, and 8 weeks.
Measured mean circulatory filling pressure (MCFP) by brief right atrial balloon inflation and derived MCFP-blood volume curves by rapid blood volume shifts of ±10%.
Determined cardiac output using Fick's principle and measured arterial pressure-volume relationships in anesthetized rats.
Mean arterial pressure remained unchanged at 1 week, rose at 2 weeks, and escalated further through week 8, while cardiac output was unchanged across all time points.
Blood volume and total vascular capacity increased at 2 weeks, normalized at 5 weeks, and contracted below baseline at 8 weeks.
MCFP, total vascular compliance, and unstressed volume showed no significant changes at 2, 5, and 8 weeks, whereas arterial compliance declined at 5 and 8 weeks.

Structured PICO

Does DOCA-salt treatment alter the circulatory pressure-volume relationship and cardiac output in rats?

Population

Rats (conscious and anesthetized)

Intervention

DOCA-salt treatment

Comparator

Sham treatment

Outcome

Total vascular pressure-volume relationship (mean circulatory filling pressure, blood volume) and cardiac outputsurrogate

Altered total vascular capacity in DOCA-salt hypertensive rats may serve to maintain normal cardiac output against rising afterload.

Cite This Study

Yamamoto et al. (1983) studied this question.

synapsesocial.com/papers/6a70abb0e36a167817e27e5d https://doi.org/10.1161/01.hyp.5.4.507

Topics

Hypertension management

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Implication

Altered vascular capacity may preserve cardiac output against rising afterload in this rat model; leaves open relevance to human hypertension.

Circulatory pressure-volume relationship and cardiac output in DOCA-salt rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Circulatory pressure-volume relationship and cardiac output in DOCA-salt rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider