November 1, 2010EuroIntervention
Long-term outcome of percutaneous closure of secundum-type atrial septal defects in adults
Why the study?
Does the Cardioseal/Starflex device compared to the Amplatzer device increase major complications in adults undergoing percutaneous closure of secundum-type ASD?
Population
133 adult patients with secundum-type atrial septal defect (ASD), mean age 46.8 years, 36 men.
Comparison
Percutaneous ASD closure using the… vs Percutaneous ASD closure using the Amplatzer ASD…
Design
Cohort
Follow-up
mean 3.4 ± 2.8 years
Authors
Discussion
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Member takes
Implication
May warrant avoiding Cardioseal/Starflex for ASD closure due to embolization risk; leaves open confirmation in randomized trials.
Structured PICO
Does the Cardioseal/Starflex device compared to the Amplatzer device increase major complications in adults undergoing percutaneous closure of secundum-type ASD?
P
Population
133 adult patients with secundum-type atrial septal defect (ASD), mean age 46.8 years, 36 men.
I
Intervention
Percutaneous ASD closure using the Cardioseal/Starflex device (n=29)
C
Comparator
Percutaneous ASD closure using the Amplatzer ASD occluder (n=104)
O
Outcome
Occurrence of major complications during long-term follow-upsafety
Percutaneous ASD closure in adults is safe and effective with the Amplatzer device, whereas the Cardioseal/Starflex device is associated with a significantly higher rate of major complications, specifically embolization.
Limitations
- Lack of randomization
Cite This Study
Luermans et al. (2010) studied this question.