Population
Aichi virus and its leader protein mutants
Comparison
Deletion mutations in the L protein vs Wild type Aichi virus
Design
Preclinical
Authors
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Aichi virus L protein has separable roles in replication and encapsidation; leaves open whether this informs picornavirus-specific antivirals.
The Aichi virus leader protein is essential for both viral RNA replication and encapsidation, distinguishing its function from other picornaviruses.
Sasaki et al. (2003) studied this question.
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