What question did this study set out to answer?

To report a rare case of infection-provoked macrophage activation syndrome (MAS) in a patient with mixed connective tissue disease (MCTD) and concurrent infections.

August 3, 2026The Journal of Rheumatology

An Unusual Case of Infection-Provoked Macrophage Activation Syndrome in Mixed Connective Tissue Disease

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Authors

RNRoko NikolicUniversity of Calgary ECErin CarterHospital for Special Surgery MLMaggie LarchéUniversity of Calgary

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Implication

Case report demonstrates infection-triggered macrophage activation syndrome in an adult with mixed connective tissue disease, suggesting clinical vigilance.

Key Points

To report a rare case of infection-provoked macrophage activation syndrome (MAS) in a patient with mixed connective tissue disease (MCTD) and concurrent infections.
Described a case of a 65-year-old male diagnosed with MCTD and presenting with CMV viremia and C. difficile colitis.
Performed clinical evaluations and initiated treatment with methylprednisolone, anakinra, and other immunosuppressive agents.
Monitored laboratory parameters including hemoglobin, ferritin, and C-reactive protein during treatment.
The patient exhibited new bicytopenia (hemoglobin 78 g/L), hyperferritinemia (peak 6751 μg/L), and clinical symptoms aligning with MAS.
Treatment with methylprednisolone and anakinra led to clinical and biochemical improvement.
Identified only two other adult cases of MAS related to MCTD in the context of infection, demonstrating rarity of this condition.

Cite This Study

Nikolic et al. (2026) studied this question.

synapsesocial.com/papers/6a70402f75942ff7265e4e0d https://doi.org/10.3899/jrheum.2026-0447.46

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Implication

Case report demonstrates infection-triggered macrophage activation syndrome in an adult with mixed connective tissue disease, suggesting clinical vigilance.

An Unusual Case of Infection-Provoked Macrophage Activation Syndrome in Mixed Connective Tissue Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

An Unusual Case of Infection-Provoked Macrophage Activation Syndrome in Mixed Connective Tissue Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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