What question did this study set out to answer?

This report details a life-threatening case of macrophage activation syndrome in a patient with mixed connective tissue disease.

Macrophage Activation Syndrome in Mixed Connective Tissue Disease: A Case of Multisystem Crisis and Recovery

View Full Paper

Ask AI

Bookmark

Authors

Case report highlights challenges and recovery from macrophage activation syndrome in a young adult with mixed connective tissue disease.

This report details a life-threatening case of macrophage activation syndrome in a patient with mixed connective tissue disease.
28-year-old female presented with febrile illness and symptoms consistent with macrophage activation syndrome.
Initial treatment included pulse IV methylprednisolone, Anakinra, and continuation of Rinvoq.
Multispecialty coordination involving Cardiology, Neurology, Nephrology, and others for comprehensive care.
Following initiation of Emapalumab, the patient stabilized and was extubated on day 5 post-arrest.
Laboratory markers improved significantly, including a decrease in ferritin levels from 10,827 μg/L to 982 μg/L.
Post-ICU complications included ongoing neurological symptoms and digital gangrene, necessitating continued vigilance.

Shaikh et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark