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August 3, 2026Molecular CancerOpen Access

Non-histone protein L-lactylation in cancer: a metabolic switch for immune evasion and therapeutic resistance

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Authors

YGYingli GuoLGLanyang GaoSLShunda Li

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Overview

Randomized trial uncovers metabolic switch effects on immune evasion and resistance in cancer, indicating novel intervention strategies.

Key Points

  • This research aims to explore the role of non-histone L-lactylation in cancer biology and its implications for immune evasion and therapeutic resistance.
  • Comprehensive overview of non-histone L-lactylation in cancer biology
  • Detailing the catalytic networks of nuclear EP300/CBP, cytosolic AARS1, and mitochondrial AARS2
  • Examination of stereospecific modifications and resulting physicochemical alterations
  • L-lactylation enhances cancer cell metabolic flexibility, promoting DNA repair and immunosuppression
  • Alterations in protein biophysics impact enzymatic kinetics and subcellular processes
  • Cancer cells exploit L-lactylation for adaptive resistance across various therapies

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a70403e75942ff7265e5079https://doi.org/10.1186/s12943-026-02759-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability2026 · 8 citations
  2. 2Non-histone lactylation in cancer: current advances and clinical implications2026
  3. 3Lactate metabolism and protein lactylation in cancer2026 · 7 citations
  4. 4Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies2025 · 23 citations
  5. 5Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets2026 · 2 citations