July 1, 1995Journal of VirologyOpen Access

Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations

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Population

Mutated poliovirus genomes with lethal lesions in 2C or 3D polymerase coding sequence

Design

Preclinical

Authors

NTNatalya L. TeterinaLomonosov Moscow State University WZWeidong ZhouShandong University MCM W ChoUniversity of California, Irvine

Discussion

Member takes

Implication

Hypothesis-generating for enteroviral replication mechanisms; does not yet inform clinical strategies or antiviral design.

Structured PICO

Population

Mutated poliovirus genomes with lethal lesions in 2C or 3D polymerase coding sequence

Intervention

PV 2C or 2BC protein provided in trans (via cotransfection with helper chimeric PV-coxsackievirus genomes or expression in cells with a vaccinia virus-T7 RNA polymerase transient-expression system)

Outcome

Rescue of replication of mutated genomessurrogate

Poliovirus RNA replication shows a marked preference for proteins contributed in cis rather than in trans.

Cite This Study

Teterina et al. (1995) studied this question.

synapsesocial.com/papers/6a704068a528af2d65c36a54 https://doi.org/10.1128/jvi.69.7.4245-4254.1995

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Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider