Why the study?
Does high-dose atorvastatin alter USPIO uptake in carotid plaques as measured by quantitative T2* MRI compared to low-dose atorvastatin in patients with >40% carotid stenosis?
Population
40 patients with >40% carotid stenosis
Comparison
High-dose statin therapy (atorvastatin 80 mg) vs Low-dose statin therapy (atorvastatin 10 mg)
Design
RCT, Randomised to low- and high-dose statin therapy
Follow-up
12 weeks
Authors
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High-dose atorvastatin may reduce USPIO-detectable inflammation in carotid stenosis; extends RCT evidence for quantitative T2* MRI as a responsive plaque biomarker.
Does high-dose atorvastatin alter USPIO uptake in carotid plaques as measured by quantitative T2* MRI compared to low-dose atorvastatin in patients with >40% carotid stenosis?
Quantitative T2* MRI can effectively measure changes in USPIO uptake in carotid plaques in response to different doses of statin therapy.
Patterson et al. (2010) studied this question.
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