Kinetic Mechanism and Regulation of Myosin VI

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Population

Myosin VI (actomyosin VI ATPase cycle, double-headed myosin VI, mutant mimicking heavy chain phosphorylation)

Design

Preclinical

Authors

Discussion

Phosphorylation tunes myosin VI Pi release for tension maintenance; leaves open relevance to human cardiac myosins.

Population

Myosin VI (actomyosin VI ATPase cycle, double-headed myosin VI, mutant mimicking heavy chain phosphorylation)

Intervention

Kinetic analysis and mutant mimicking heavy chain phosphorylation (HCP)

Outcome

Kinetic parameters of the actomyosin VI ATPase cycle (ADP release rate, ATP binding, P(i) release rate)surrogate

Myosin VI is a high duty ratio motor adapted for maintaining tension, with heavy chain phosphorylation regulating P(i) release.

Cruz et al. (2001) studied this question.

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