Population
CCS embryonic stem cells possessing two mutant alleles for the skeletal muscle ryanodine receptor injected…
Comparison
Transient transfection with full-length rabbit… vs Untransfected 1B5 cells lacking RyR expression.
Design
Preclinical
Authors
Loading...
Establishes 1B5 cells as a null-background system for RyR studies; leaves open translation to cardiac disease models.
The development of the 1B5 cell line lacking endogenous ryanodine receptors provides a powerful homologous expression system for studying Ry1R structure and function.
Moore et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: