February 1, 1997AJP Cell Physiology

Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells

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Population

Junctional sarcoplasmic reticulum (SR) vesicles from rabbit skeletal muscle and differentiated BC3H1 cells

Comparison

Bastadins alone or in combination with ryanodine… vs Control conditions

Design

Preclinical

Authors

IPIsaac N. PessahUniversity of California, Davis TMTadeusz F. MolinskiScripps Institution of Oceanography TMT. D. Meloy

Discussion

Member takes

Implication

Does not support clinical use; hypothesis-generating for RyR-FKBP modulation in muscle Ca2+ disorders.

Structured PICO

Population

Junctional sarcoplasmic reticulum (SR) vesicles from rabbit skeletal muscle and differentiated BC3H1 cells

Intervention

Bastadins (including Bastadin 5) alone or in combination with ryanodine or ruthenium red

Comparator

Control conditions (ryanodine or ruthenium red alone, thapsigargin alone)

Outcome

Ca2+ efflux/leak and steady-state loading capacity of SR vesiclessurrogate

Bastadins modulate the FKBP12-Ry1R complex to convert ryanodine-insensitive Ca2+ leak states into ryanodine-sensitive channels in skeletal muscle SR and BC3H1 cells.

Cite This Study

Pessah et al. (1997) studied this question.

synapsesocial.com/papers/6a70443db27f158178274658 https://doi.org/10.1152/ajpcell.1997.272.2.c601

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Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider