What question did this study set out to answer?

To examine the relationship between blood–brain barrier (BBB) permeability across various brain regions and total MRI burden of cerebral small vessel disease (cSVD).

April 6, 2018Frontiers in NeurologyOpen Access

Compromised Blood–Brain Barrier Integrity Is Associated With Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease

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To examine the relationship between blood–brain barrier (BBB) permeability across various brain regions and total MRI burden of cerebral small vessel disease (cSVD).
Enrolled 99 consecutive stroke-free individuals presenting for physical examination (mean age 70.33 years, range 49–90).
Calculated total MRI cSVD burden on an ordinal scale (0–4) evaluating lacunes, white matter hyperintensities (WMH), cerebral microbleeds, and enlarged perivascular spaces.
Measured BBB permeability and fractional blood plasma volume in normal-appearing white matter (NAWM), WMH, cortical gray matter (CGM), and deep gray matter (DGM) using dynamic contrast-enhanced MRI (DCE-MRI) and the Patlak pharmacokinetic model.
Multivariable linear regression adjusted for age, sex, and vascular risk factors revealed that leakage rate and area under the leakage curve across NAWM, WMH, CGM, and DGM were positively associated with total MRI cSVD burden (all P < 0.01).
Fractional blood plasma volumes in NAWM, CGM, and DGM were negatively associated with total MRI cSVD burden (all P < 0.05).

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Implication

Cross-sectional study finds higher blood–brain barrier leakage tracks with total cerebral small vessel disease burden in older adults, indicating microvascular compromise contributes to disease.

Cite This Study

Li et al. (2018) studied this question.

synapsesocial.com/papers/6a70457afebe604dd7090d7d https://doi.org/10.3389/fneur.2018.00221

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Implication

Cross-sectional study finds higher blood–brain barrier leakage tracks with total cerebral small vessel disease burden in older adults, indicating microvascular compromise contributes to disease.

Compromised Blood–Brain Barrier Integrity Is Associated With Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease

Key Points

Discussion

Implication

Cite This Study

Compromised Blood–Brain Barrier Integrity Is Associated With Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease

Key Points

Discussion

Implication

Cite This Study

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