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March 4, 2025Journal of Sports Sciences

Hypoxia combined with body weight reduction increased RPE and [HHb] compared to normoxic equivalent conditions (p < 0.05), while HR remained lower than the 100% BW control (p < 0.05).

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Why the study?

The study investigated the effects of body weight reduction and hypoxia on physiological and perceptual responses during high-intensity interval exercise on an anti-gravity treadmill.

Does the combination of body weight reduction and hypoxia alter physiological and perceptual responses during high-intensity interval exercise in endurance athletes?

Population

26 participants (12 women)

Comparison

5 randomized conditions of normoxia vs hypoxia across 100%, 80%, and 60% body weight

Design

Randomized crossover study

Authors

MCMarie Chambion-DiazUniversité Claude Bernard Lyon 1JCJ ChertinUniversité LavalVPVincent PialouxUniversité Claude Bernard Lyon 1

Discussion

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Overview

Hypoxia may offset cardiometabolic unloading from BW reduction during HIIE; leaves open optimal protocols for training or rehab.

Structured PICO

Does the combination of body weight reduction and hypoxia alter physiological and perceptual responses during high-intensity interval exercise in endurance athletes?

P
Population
26 endurance athletes (12 women), mean age 26.2 years, mean VO2max 61.1 mL/min/kg
I
Intervention
High-intensity interval exercise (HIIE) on an anti-gravity treadmill with body weight reduction (80% or 60% BW) and/or hypoxia (FIO2 = 0.14)
C
Comparator
Normoxia at 100% body weight (control)
O
Outcome
Physiological and perceptual responses including heart rate (HR), pulse arterial O2 saturation (SpO2), muscle deoxyhemoglobin concentration ([HHb]), rate of perceived exertion (RPE), and blood lactate concentration ([Lac−])surrogate

Hypoxia can effectively restore physiological stress during high-intensity interval exercise with reduced body weight, offering a potential strategy for athletic rehabilitation and performance.

Cite This Study

Chambion-Diaz et al. (2025) studied this question.

synapsesocial.com/papers/6a7045c7febe604dd7090deehttps://doi.org/10.1080/02640414.2025.2474333
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise responses to perceptually regulated high intensity interval exercise with continuous and intermittent hypoxia in inactive overweight individuals2025
  2. 2Acute psycho-physiological responses to submaximal constant-load cycling under intermittent hypoxia-hyperoxia <i>vs</i>. hypoxia-normoxia in young males2024 · 2 citations
  3. 3Hypoxic high-intensity interval training in individuals with overweight and obesity2022 · 21 citations
  4. 4The Acute Physiological and Perceptual Responses Between Bodyweight and Treadmill Running High-Intensity Interval Exercises2022 · 21 citations
  5. 5Inter-effort hypoxia recovery during high-intensity intermittent exercise enhances oxygen uptake at the onset of efforts while maintaining exercise tolerance2026