What question did this study set out to answer?

To evaluate the duration of the blood pressure-lowering effect, angiotensin I inhibition, and bradykinin potentiation following converting-enzyme inhibition in normotensive and renovascular hypertensive rats.

November 1, 1983HypertensionOpen Access

Protracted effect of converting-enzyme inhibition on the rat's response to intraarterial bradykinin.

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Why the study?

Does intravenous MK422 alter blood pressure and bradykinin responses in normotensive and renovascular hypertensive rats?

Population

Normotensive control rats and two-kidney, one clip (2K1C) rats in the acute phase of renovascular hypertension

Design

Preclinical

Follow-up

24 hours

Authors

CLC.J. LindseyNational Council for Scientific and Technological Development ÚPÚrsula PaulaSanta Paula Hospital APAntonio C.M. PaivaHospital Pulido Valente

Discussion

Member takes

Implication

Prolonged MK422 effects in rats leave open tissue ACE and bradykinin contributions to hypotension; human translation untested.

Key Points

To evaluate the duration of the blood pressure-lowering effect, angiotensin I inhibition, and bradykinin potentiation following converting-enzyme inhibition in normotensive and renovascular hypertensive rats.
Administered intravenous MK422 (1 mg/kg/hr for 30 minutes) to normotensive control rats and two-kidney, one-clip (2K1C) renovascular hypertensive rats.
Assessed blood pressure responses to intraarterial and intravenous challenges of angiotensin I and bradykinin at 1 hour and 24 hours post-infusion.
MK422 infusion produced a significant hypotensive effect that persisted through 24 hours in both normotensive and hypertensive rat models.
Inhibition of pressor responses to angiotensin I and potentiation of depressor responses to intravenous bradykinin dissipated by 24 hours, while potentiation of intraarterial bradykinin persisted for 24 hours.

Structured PICO

Does intravenous MK422 alter blood pressure and bradykinin responses in normotensive and renovascular hypertensive rats?

Population

Normotensive control rats and two-kidney, one clip (2K1C) rats in the acute phase of renovascular hypertension

Intervention

Intravenous infusion of the converting-enzyme (CE) inhibitor MK422 (1 mg/kg/hr for 30 minutes)

Outcome

Hypotensive effect and pressor/depressor responses to angiotensin I and bradykinin at 1 hour and 24 hours post-infusionsurrogate

The prolonged hypotensive effect of the CE inhibitor MK422 in rats may be mediated by tissue CE inhibition and increased endogenous bradykinin.

Cite This Study

Lindsey et al. (1983) studied this question.

synapsesocial.com/papers/6a7045f0c1a24a6142db79dc https://doi.org/10.1161/01.hyp.5.6_pt_3.v134

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Protracted effect of converting-enzyme inhibition on the rat's response to intraarterial bradykinin.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Protracted effect of converting-enzyme inhibition on the rat's response to intraarterial bradykinin.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider