October 1, 1999American Journal of HypertensionOpen Access

Effect of chronic angiotensin converting enzyme inhibition on angiotensin I and bradykinin metabolism in rats

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Population

Male Wistar rats

Comparison

Enalapril 10 mg/kg orally once a day for 7 to 15… vs Vehicle-treated rats for 7 to 30 days

Design

Preclinical

Follow-up

up to 30 days

Authors

LSLeonilda StanziolaUniversidade Federal de Uberlândia

Discussion

Member takes

Implication

Does not support changing ACEI use; leaves open whether chronic effects induce similar pathways in patients.

Structured PICO

Population

Male Wistar rats (n=42 total: 20 treated for 7-15 days, 11 treated for 21-30 days, 11 vehicle-treated controls)

Intervention

Enalapril 10 mg/kg orally once a day for 7 to 15 days or 21 to 30 days

Comparator

Vehicle-treated rats for 7 to 30 days

Outcome

In vivo pulmonary inactivation of bradykinin (BK) and conversion of angiotensin I (Ang I)surrogate

Chronic ACE inhibition with enalapril in rats induces alternative bradykinin-inactivating mechanisms and increases angiotensin-(1-7)-generating mechanisms.

Cite This Study

Leonilda Stanziola (1999) studied this question.

synapsesocial.com/papers/6a71eaa578a11c550e0bda3e https://doi.org/10.1016/s0895-7061(99)00090-4

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