Why the study?
Is the ACE insertion/deletion polymorphism associated with angiographically proven coronary artery disease in South Indian subjects?
Is the ACE insertion/deletion polymorphism associated with angiographically proven coronary artery disease in South Indian subjects?
The ACE DD genotype and D allele are significantly associated with an increased risk of angiographically proven coronary artery disease in a South Indian population.
ACE DD genotype associated with CAD in South Indians; leaves open whether genotyping aids risk prediction or warrants prospective validation.
The prevalence of Coronary artery disease (CAD) varies epidemiologically among different population. Environmental and genetic factors play an important role in the pathogenesis of CAD. Angiotensin converting enzyme (ACE) insertion/deletion polymorphism has an effect on the pathogenesis of CAD, through angiotensin II mediated mechanism. In the present study, we have evaluated the association of insertion/deletion polymorphism in angiographically proven CAD patients (n= 50) by comparing with controls (n=54). We found that DD polymorphism is highly significant in CAD subjects (46%) D allele frequency is high in CAD subjects (63%) vs Controls 33%. The odds ratio for developing CAD is high in DD genotype than in ID/II genotypes with p value of <0.001. Thus by this study we conclude that DD polymorphism is associated with CAD in south Indian subjects. Key words: Angiotensin converting enzyme, gene polymorphism, coronary artery disease (CAD).
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Phanikrishna et al. (2012) studied this question.
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