Why the study?
Is the DCP1 genotype associated with late-onset Alzheimer disease?
Is the DCP1 genotype associated with late-onset Alzheimer disease?
The study found no association between the DCP1 genotype and late-onset Alzheimer disease, failing to confirm previous positive association findings.
No DCP1 association with late-onset AD observed; leaves open replication in larger, diverse cohorts before ruling out a role.
In a study of 261 patients with Alzheimer disease (AD) and 306 cognitively normal control subjects from Germany, Switzerland, and Italy, we found no association between genotype counts or allelic frequencies of DCP1, the gene encoding angiotensin-converting enzyme. In accordance with several other studies, our data could not confirm previous association findings. Critical review about all studies available on DCP1 genotyping and AD, age-associated cognitive decline, longevity, and other conditions revealed remarkable inconsistencies. Several studies showed significant deviations of genotype counts from Hardy Weinberg equilibrium (HWE). Deviations from HWE may limit the comparability of study results and require clarification before drawing conclusions with respect to disease risk, health conditions, or longevity in association with DCP1 genotype.
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Buss et al. (2002) studied this question.
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