What question did this study set out to answer?

To evaluate adverse drug reaction reports of persistent cough associated with the use of captopril and enalapril.

June 13, 1987BMJOpen Access

Cough associated with captopril and enalapril.

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Why the study?

Is cough an adverse reaction associated with captopril and enalapril therapy?

To evaluate adverse drug reaction reports of persistent cough associated with the use of captopril and enalapril.
Reviewed 33 reports of captopril-associated cough and 26 reports of enalapril-associated cough submitted to the New Zealand Intensive Medicines Monitoring Programme.
Cough occurred even at low doses and was severe enough to require drug discontinuation in most reported cases, with a significant female predominance.
The adverse reaction appeared more pronounced with enalapril, recurred in seven patients receiving both medications, and rapidly resolved following drug withdrawal with no long-term sequelae.

Is cough an adverse reaction associated with captopril and enalapril therapy?

Population

59 reports of cough associated with captopril (n=33) and enalapril (n=26) received by the New Zealand intensive medicines monitoring programme

Intervention

Captopril or enalapril

Outcome

Cough as an adverse reactionsafety

This pharmacovigilance report highlights cough as a significant, reversible adverse effect of ACE inhibitors, with a higher prevalence in women.

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Cough may prompt ACE inhibitor withdrawal in women; leaves open incidence and risk quantification in prospective cohorts.

Coulter et al. (1987) studied this question.

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