Key result
Enalapril induces a dry cough not seen with captopril in a hypertensive woman.
Why the study?
Does enalapril induce dry cough compared to captopril in a patient with hypertension?
Does enalapril induce dry cough compared to captopril in a patient with hypertension?
This case report highlights that ACE inhibitor-induced cough may be specific to certain agents like enalapril and not necessarily a class effect shared with captopril.
ACEI cough may not be a uniform class effect; hypothesis-generating for agent-specific differences in hypertension.
We report a 68 yr old woman with hypertension who developed a dry cough on enalapril but not on captopril therapy. Pulmonary function tests, methacholine inhalation challenges, total blood eosinophil counts, and changes in plasma concentrations of prostaglandin E2 and thromboxane B2 did not explain the difference in the adverse reaction between these two angiotensin converting enzyme inhibitors.
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Puolijoki et al. (1989) studied this question. Enalapril therapy induced a dry cough in a hypertensive woman that did not occur with captopril, a difference unexplained by pulmonary function or biochemical tests.
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