The Relation Between Clinical Edema and the Excretion of an Antidiuretic Substance in the Urine

Article1 July 1940THE RELATION BETWEEN CLINICAL EDEMA AND THE EXCRETION OF AN ANTIDIURETIC SUBSTANCE IN THE URINEFRANK H. ROBINSON JR., M.D., LEE E. FARR, M.D.FRANK H. ROBINSON JR., M.D., LEE E. FARR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-1-42 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStarling's hypothesis relating the exchange of fluid between the capillaries and the interstitial body fluids to a balance between hydrostatic pressure within the capillaries and osmotic pressure of the plasma proteins, permits prediction of some conditions under which edema will be found. Moore and Van Slyke1found that in adults with Bright's disease when the plasma albumin level fell below 2.5 grams per 100 c.c. edema almost invariably occurred and could not be controlled by salt restriction alone. Farr and Van Slyke2found that in similar circumstances the plasma albumin of children averaged 1.2 grams per 100 c.c. Direct measurements...Bibliography1. MOOREVAN SLYKE NSDD: The relationships between plasma specific gravity, plasma protein content and edema in nephritis, Jr. Clin. Invest., 1930, viii, 337. CrossrefGoogle Scholar2. FARRVAN SLYKE LEDD: Relation between plasma protein level and edema in nephrotic children, Am. Jr. Dis. Child., 1939, lvii, 306. Google Scholar3. BOURDILLON J: Osmotic pressure study of protein fractions in normal and nephrotic subjects, Jr. Exper. Med., 1939, lxix, 819. CrossrefGoogle Scholar4. PETERSVAN SLYKE JPDD: Quantitative clinical chemistry, 1931, Vol. 1, p. 669, Williams and Wilkins, Baltimore. Google Scholar5. GILMANGOODMAN AL: The secretory response of the posterior pituitary to the need for water conservation, Jr. Physiol., 1937, xc, 113. CrossrefGoogle Scholar6. BURN JH: Estimation of the antidiuretic potency of pituitary (posterior lobe) extract, Quart. Jr. Pharm. and Pharmacol., 1931, iv, 517. Google Scholar7. VAN SLYKEHASTINGSHILLERSENDROY DDABAJ: Studies of gas and electrolyte equilibria in blood. XIV. The amounts of alkali bound in serum albumin and globulin, Jr. Biol. Chem., 1928, lxxix, 769. CrossrefGoogle Scholar8. THALHIMER W: A simple inexpensive method for concentrating serum under sterile conditions, Proc. Soc. Exper. Biol. and Med., 1938, xxxvii, 639. CrossrefGoogle Scholar9. MCQUARRIETHOMPSONZIEGLER IWHMR: Effects of posterior pituitaryextract on water and mineral exchanges in edema, Jr. Pediat., 1936, viii, 277. CrossrefGoogle Scholar10. TEELREID HMDE: Observation upon the occurrence of an antidiuretic substance in the urine of patients with preeclampsia and eclampsia, Endocrinology, 1939, xxiv, 297. CrossrefGoogle Scholar11. INGRAMLADDBENBOW WRLJT: The excretion of antidiuretic substance and its relation to the hypothalamico-hypophyseal system in cats, Am. Jr. Physiol., 1939, cxxvii, 544. CrossrefGoogle Scholar12. WALKER AM: Experiments upon the relation between the pituitary gland and water diuresis, Am. Jr. Physiol., 1939, cxxvii, 519. CrossrefGoogle Scholar13. HARE K: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read before the American College of Physicians, Cleveland, Ohio, April 3, 1940.From the Hospital of the Rockefeller Institute for Medical Research, New York.†Dr. Robinson died November 1939. 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