Why the study?
Pulmonary valve replacement is required for RVOT dysfunction, and PPVI offers a less-invasive option, but its effectiveness, safety, and optimal timing needed evaluation.
Does percutaneous pulmonary valve implantation improve mean RVOT gradient and right ventricular remodeling in patients with right ventricular outflow tract dysfunction?
Population
1246 participants with RVOT dysfunction across 20 studies
Comparison
PPVI (single-arm evaluation)
Design
Systematic review and meta-analysis
Authors
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PPVI supports less-invasive management of RVOT dysfunction with hemodynamic gains; leaves open optimal timing and durability pending RCTs.
Does percutaneous pulmonary valve implantation improve mean RVOT gradient and right ventricular remodeling in patients with right ventricular outflow tract dysfunction?
Percutaneous pulmonary valve implantation is highly successful and significantly improves hemodynamics and right ventricular remodeling in patients with RVOT dysfunction, with acceptable complication rates.
Ran et al. (2019) studied this question.
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