March 28, 2008Diabetes CareOpen Access

Plasma Concentration of Asymmetric Dimethylarginine (ADMA) Predicts Cardiovascular Morbidity and Mortality in Type 1 Diabetic Patients With Diabetic Nephropathy

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Why the study?

Does elevated plasma ADMA predict cardiovascular events and renal decline in type 1 diabetic patients with diabetic nephropathy?

Population

572 type 1 diabetic patients, comprising 397 with overt diabetic nephropathy and a control group of 175…

Comparison

Elevated plasma asymmetric dimethylarginine levels vs Lower plasma ADMA levels (below the median)

Design

Cohort

Follow-up

median 11.3 years (range 0.0-12.9)

Authors

MLMaria LajerBoehringer Ingelheim (Denmark)LTLise TarnowHeart Failure & Transplant AJAnders JorsalRegional Hospital Horsens

Discussion

Member takes

Implication

May identify higher-risk type 1 diabetic nephropathy patients; leaves open whether ADMA refines risk stratification beyond conventional factors.

Structured PICO

Does elevated plasma ADMA predict cardiovascular events and renal decline in type 1 diabetic patients with diabetic nephropathy?

Population

572 type 1 diabetic patients, comprising 397 with overt diabetic nephropathy (243 men, mean age 42.1 +/- 10.5 years, GFR 76 +/- 34 ml/min per 1.73 m2) and a control group of 175 patients with longstanding type 1 diabetes and persistent normoalbuminuria (104 men, mean age 42.7 +/- 9.7 years, duration of diabetes 27.7 +/- 8.3 years).

Intervention

Elevated plasma asymmetric dimethylarginine (ADMA) levels (above the median)

Comparator

Lower plasma ADMA levels (below the median)

Outcome

Fatal and nonfatal cardiovascular disease (CVD), decline in GFR, ESRD, and all-cause mortalityhard clinical

Elevated plasma ADMA levels are an independent predictor of fatal and nonfatal cardiovascular events and progressive kidney disease in patients with type 1 diabetic nephropathy.

Cite This Study

Lajer et al. (2008) studied this question.

synapsesocial.com/papers/6a70469e2163a0a01bc47ebd https://doi.org/10.2337/dc07-1762

Topics

Women and heart disease

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Implication

May identify higher-risk type 1 diabetic nephropathy patients; leaves open whether ADMA refines risk stratification beyond conventional factors.

Plasma Concentration of Asymmetric Dimethylarginine (ADMA) Predicts Cardiovascular Morbidity and Mortality in Type 1 Diabetic Patients With Diabetic Nephropathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Plasma Concentration of Asymmetric Dimethylarginine (ADMA) Predicts Cardiovascular Morbidity and Mortality in Type 1 Diabetic Patients With Diabetic Nephropathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider