Why the study?
Does elevated plasma ADMA associate with diabetic nephropathy and cardiovascular morbidity in patients with type 1 diabetes?
Population
600 patients with longstanding type 1 diabetes, including 408 with overt diabetic nephropathy and 192 with…
Comparison
Elevated plasma asymmetric dimethylarginine… vs Lower plasma ADMA concentrations /…
Design
Cross-sectional
Authors
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Supports ADMA as a marker of nephropathy and CV events in type 1 diabetes; leaves open prospective validation and therapeutic targeting.
Does elevated plasma ADMA associate with diabetic nephropathy and cardiovascular morbidity in patients with type 1 diabetes?
Elevated circulating ADMA is associated with diabetic nephropathy and a history of major cardiovascular events in patients with type 1 diabetes, suggesting it may serve as a marker for cardiovascular morbidity.
Tarnow et al. (2004) studied this question.
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