Why the study?
Does losartan reduce albuminuria compared to amlodipine in hypertensive Japanese patients with type 2 diabetes mellitus?
Population
35 Japanese patients with hypertension and type 2 diabetes mellitus, mean age ~58 years, ~57% male.
Comparison
Losartan 25-100 mg/d for 3 months vs Amlodipine 2.5-5 mg/d for 3 months
Design
RCT, randomly assigned to 1 of 2 study groups, open-label
Follow-up
3 months
Authors
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Losartan may be preferred to amlodipine for albuminuria reduction in hypertensive T2DM; extends RCT evidence for ARB renoprotection independent of GFR.
Does losartan reduce albuminuria compared to amlodipine in hypertensive Japanese patients with type 2 diabetes mellitus?
Losartan, but not amlodipine, significantly reduced albuminuria independent of GFR changes in hypertensive Japanese patients with type 2 diabetes over a 3-month period.
Ohno et al. (2007) studied this question.
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