Why the study?
Does MPEG-IL-6 improve thrombopoietic activity compared to native IL-6 in mice?
Population
Mice (including normal mice and mice treated with 5-fluorouracil)
Comparison
Polyethylene glycol-modified interleukin-6… vs Native IL-6 administered subcutaneously every 2…
Design
Preclinical
Follow-up
7 days
Authors
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Does not support clinical use; leaves open translation of MPEG-IL-6 to human thrombopoiesis.
Does MPEG-IL-6 improve thrombopoietic activity compared to native IL-6 in mice?
PEGylation of IL-6 significantly increases its thrombopoietic potency and plasma half-life in mice, suggesting potential as a thrombopoietic agent.
Tsutsumi et al. (1997) studied this question.
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