Population
Normal Balb/c mice
Comparison
Pegylated recombinant human megakaryocyte growth… vs Nonpegylated form of recombinant human…
Design
Preclinical
Follow-up
8 days
Authors
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Supports preclinical thrombopoiesis research in mice; leaves open translation to human thrombocytopenia therapies.
PEG-rHuMGDF is a potent stimulator for megakaryopoiesis and thrombopoiesis in normal mice, with dose-dependent effects on platelet counts and volume.
Kabaya et al. (1996) studied this question.
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