Treatment of Typhoid Fever. Ii. Control of Clinical Manifestations With Cortisone

Article1 January 1951TREATMENT OF TYPHOID FEVER. II. CONTROL OF CLINICAL MANIFESTATIONS WITH CORTISONET. E. WOODWARD, M.D., H. E. HALL, M.D., R. DIAS-RIVERA, M.D., J. A. HIGHTOWER, M.D., E. MARTINEZ, M.D., R. T. PARKER, M.D.T. E. WOODWARD, M.D.Search for more papers by this author, H. E. HALL, M.D.Search for more papers by this author, R. DIAS-RIVERA, M.D.Search for more papers by this author, J. A. HIGHTOWER, M.D.Search for more papers by this author, E. MARTINEZ, M.D.Search for more papers by this author, R. T. PARKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-1-10 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the obvious benefits of chloramphenicol therapy in typhoid fever,1, 2there are several problems in this disease which remain to be solved: (1) The present chloramphenicol regimens do not alleviate the toxemia of the disease for at least 36 to 48 hours and fail to eliminate the fever until about the fourth day; (2) relapses of typhoid fever occur in a certain percentage of treated patients3; (3)Salmonella typhosacontinues to be shed in the feces for variable periods of time after therapy is begun,2and (4) the typhoid carrier state when it exists is not permanently benefited by...Bibliography1. WoodwardSmadelLeyGreenMankikar TEJEHLRDS: Preliminary report on the beneficial effect of chloromycetin in the treatment of typhoid fever, Ann. Int. Med. 29: 131, 1948. LinkGoogle Scholar2. WoodwardSmadelLey TEJEHL: Chloramphenicol and other antibiotics in the treatment of typhoid fever and typhoid carriers, J. Clin. Investigation 29: 87-99, 1950. CrossrefMedlineGoogle Scholar3. SmadelWoodwardBailey JETECA: Relation of relapses in typhoid to duration of chloramphenicol therapy, J. A. M. A. 141: 129, 1949. CrossrefMedlineGoogle Scholar4. LewisPage LAIH: Studies on the protective power of adrenal extract and steroids against bacterial toxins in adrenalectomized rats. Appendix 1 to: Kendall, E. C., The Chemistry and partial synthesis of adrenal steroids, Ann. New York Acad. Sc. 50: 547, 1949. CrossrefMedlineGoogle Scholar5. JacksonSmadel EBJE: Cortisone and ACTH on toxins of rickettsial and Salmonella typhosa , Bact. Proc., pp. 92-93, 1950. Google Scholar6. SmadelLeyDiercks JEHLFH: Therapy of typhoid fever. Part I. Combined therapy with cortisone and chloramphenicol, Ann. Int. Med. 34: 1-9, 1951. LinkGoogle Scholar7. Green R: An epidemic of typhoid fever, in: Annual report of the Institute for Medical Research for 1939, published by Federated Malay States Government Press, 1940, p. 25. Google Scholar8. Selye H: The general adaptation syndrome and the diseases of adaptation, J. Clin. Endocrinology 6: 117, 1946. CrossrefGoogle Scholar9. FinlandKossIngbar MEHSH: Effects of ACTH in primary atypical (viral) pneumonia and in pneumococcal pneumonia (preliminary report), Chapter 45 in: Mote, J. R.: Proceedings of the first clinical ACTH conference, 1950, Blakiston, Philadelphia, p. 529. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 27, 1950.From the Department of Medicine, School of Medicine, University of Maryland, Baltimore, and the Tropical Research Medical Laboratory, U. S. Army, San Juan, Puerto Rico.This study supported by a grant from Parke, Davis and Company, Detroit, Michigan; the McCormick Company, Inc., Baltimore, and the Commission of Immunization of the Armed Forces Epidemiological Board.The cortisone acetate in this study was supplied by Merck and Company, Rahway, New Jersey. 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Paratyphus. Biologische Wirkungen und NebenerscheinungenACTH and Cortisone in InfectionThe Role of Adrenal Steroids in Infection and ImmunityTREATMENT OF TYPHOID FEVER. I. COMBINED THERAPY WITH CORTISONE AND CHLORAMPHENICOL*JOSEPH E. SMADEL, HERBERT L. LEY JR., FRED H. DIERCKS 1 January 1951Volume 34, Issue 1Page: 10-19KeywordsArmed forcesChloramphenicolFeversHyperthermiaMedical staffResearch laboratoriesSalmonellaTyphoid ePublished: 1 December 2008 Issue Published: 1 January 1951 PDF downloadLoading ...