Effects of bradykinin B2 receptor antagonism on the hypotensive effects of ACE inhibition
Why the study?
Does bradykinin B2 receptor antagonism reduce the acute hypotensive effects of ACE inhibition in spontaneously hypertensive rats?
Population
Conscious spontaneously hypertensive rats (SHR) receiving either a low or a high NaCl diet
Comparison
Bradykinin B2 receptor antagonists administered… vs Perindoprilat alone, or calcium antagonist…
Design
Preclinical
Follow-up
acute
Authors
Discussion
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Member takes
Implication
Animal data implicate bradykinin in acute ACE-inhibitor hypotension in rats; leaves open relevance to human therapy.
Structured PICO
Does bradykinin B2 receptor antagonism reduce the acute hypotensive effects of ACE inhibition in spontaneously hypertensive rats?
P
Population
Conscious spontaneously hypertensive rats (SHR) receiving either a low or a high NaCl diet
I
Intervention
Bradykinin B2 receptor antagonists (B 4146 and Hoe 140) administered before or after bolus administration of 7 mg kg-1 of the ACE inhibitor perindoprilat
C
Comparator
Perindoprilat alone, or calcium antagonist nicardipine
O
Outcome
Acute hypotensive effects (blood pressure changes)surrogate
Endogenous bradykinin plays a significant role in the acute antihypertensive effects of ACE inhibitors in spontaneously hypertensive rats, particularly under high salt diet conditions.
Limitations
- The exact mechanism of this interaction remains unclear
Cite This Study
Bouaziz et al. (1994) studied this question.