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October 15, 1993Proceedings of the National Academy of SciencesOpen Access

Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1.

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Population

Rat liver cell populations isolated and placed in short-term primary culture, including cells from injured…

Design

Preclinical

Authors

CHChantal HoussetInsermDRDon C. RockeyMedical University of South CarolinaDBD. Montgomery BissellUniversity of California, San Francisco

Discussion

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Implication

May implicate ET-1 in sinusoidal perfusion control during liver injury; leaves open in vivo and human translation.

Structured PICO

P
Population
Rat liver cell populations (lipocytes, sinusoidal endothelial cells, Kupffer cells, hepatocytes) isolated and placed in short-term primary culture, including cells from injured liver (carbon tetrachloride administration)
I
Intervention
Endothelin-1 (ET-1) and Endothelin-3 (ET-3)
O
Outcome
Expression of ET receptors (ETA and ETB) and contraction of activated lipocytessurrogate

ET-1 may play a role in regulating sinusoidal perfusion through its contractile effect on hepatic lipocytes, particularly in liver injury states.

Cite This Study

Housset et al. (1993) studied this question.

synapsesocial.com/papers/6a704955a528af2d65c36fb8https://doi.org/10.1073/pnas.90.20.9266
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelin ET<sub>A</sub> and ET<sub>B</sub> receptors mediate vascular smooth muscle contraction1992 · 289 citations
  2. 2Efficient<i>in vitro</i>synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter1984 · 6,458 citations
  3. 3Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.1989 · 401 citations
  4. 4The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.1989 · 2,532 citations
  5. 5Immunocytochemical Detection of Desmin in Fat-Storing Cells (Ito Cells)1984 · 391 citations