Population
Cultured adult rat cardiac fibroblasts (passages 5-10) grown until confluence
Design
Preclinical
Authors
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Does not inform therapy; leaves open endothelin role in fibroblast-driven fibrosis pending in vivo validation.
Endothelin receptors (ETA and ETB, with ETB predominant) are present on adult rat cardiac fibroblasts, suggesting a role for endothelins in regulating cardiac fibroblast function and potential myocardial fibrosis.
Katwa et al. (1993) studied this question.
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