October 1, 1991Circulation ResearchOpen Access

Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Developmental changes in mechanical responses and receptor subtypes.

View Full Paper

Ask AI

Bookmark

Population

Rat hearts (adult and neonatal atria and ventricles)

Design

Preclinical

Authors

TITomohisa IshikawaKumamoto Orthopedic Surgery Hospital LLL M LiHuaiyin Normal University OSOsamu ShinmiUniversity of Tsukuba

Discussion

Member takes

Implication

Developmental ET receptor differences in rat heart warrant caution before human extrapolation; leaves open subtype-specific roles in cardiac maturation.

Structured PICO

Population

Rat hearts (adult and neonatal atria and ventricles)

Intervention

Endothelin-1 (ET-1) and endothelin-3 (ET-3)

Outcome

Inotropic and chronotropic effects, and binding site characteristics (affinity and Kd)surrogate

Endothelin-1 and -3 exhibit developmental changes in their mechanical responses and receptor subtypes in rat hearts, with distinct binding site profiles between neonatal and adult tissues.

Cite This Study

Ishikawa et al. (1991) studied this question.

synapsesocial.com/papers/6a853275f2bb7ee68cf23ec0 https://doi.org/10.1161/01.res.69.4.918

View Full Paper

Ask AI

Bookmark

Implication

Developmental ET receptor differences in rat heart warrant caution before human extrapolation; leaves open subtype-specific roles in cardiac maturation.

Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Developmental changes in mechanical responses and receptor subtypes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Developmental changes in mechanical responses and receptor subtypes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider