January 26, 2007DevelopmentOpen Access

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

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Population

Mouse embryos (cardiac lineage)

Design

Preclinical

Authors

Discussion

Hypothesis-generating in animal models; leaves open any clinical translation to human congenital heart defects.

Population

Mouse embryos (cardiac lineage)

Intervention

Forced expression of Hesr1 or Hesr2 in the entire cardiac lineage

Outcome

Atrioventricular (AV) canal formation and expression of AV myocardium markers (Bmp2, Tbx2)surrogate

Hesr1 and Hesr2 play crucial roles in atrioventricular boundary formation in the developing heart through the suppression of Tbx2.

Kokubo et al. (2007) studied this question.

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