April 1, 1996Journal of Biological ChemistryOpen Access

Molecular Cloning and Characterization of SmLIM, a Developmentally Regulated LIM Protein Preferentially Expressed in Aortic Smooth Muscle Cells

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Population

Rat aortic smooth muscle cells and rat vessel wall injury model, along with mouse and human homologues.

Comparison

Platelet-derived growth factor-BB and vessel… vs Untreated cells and uninjured vessel wall

Design

Preclinical

Authors

MJMukesh K. JainGandhi Medical College & Hospital KFKenji FujitaIshikawa Prefectural Central Hospital CHChung-Ming HsiehBrigham and Women's Hospital

Discussion

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Implication

Does not yet alter clinical management of vascular injury; leaves open SmLIM as a regulator of smooth muscle proliferation.

Structured PICO

Population

Rat aortic smooth muscle cells (in vitro) and rat vessel wall injury model (in vivo), along with mouse and human homologues.

Intervention

Platelet-derived growth factor-BB (in vitro) and vessel wall injury (in vivo)

Comparator

Untreated cells (in vitro) and uninjured vessel wall (in vivo)

Outcome

SmLIM mRNA expression levelssurrogate

SmLIM is a novel smooth muscle LIM protein that is down-regulated during vascular smooth muscle cell proliferation, suggesting a role in growth and differentiation.

Cite This Study

Jain et al. (1996) studied this question.

synapsesocial.com/papers/6a70499f3ce530166bc2c938 https://doi.org/10.1074/jbc.271.17.10194

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Molecular Cloning and Characterization of SmLIM, a Developmentally Regulated LIM Protein Preferentially Expressed in Aortic Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Cloning and Characterization of SmLIM, a Developmentally Regulated LIM Protein Preferentially Expressed in Aortic Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider