Key result
Overexpression of SLIM1 in skeletal muscle cell lines induced hyperelongation in differentiating myocytes and branching in reserve cells, both dependent on alpha5beta1-integrin signaling.
Population
Sol8 or C2C12 skeletal muscle cell lines
Design
Preclinical
Authors
Loading...
Cell-line overexpression supports SLIM1 in early myocyte differentiation; leaves open in vivo relevance to human muscle disease.
SLIM1 overexpression induces alpha5beta1-integrin-dependent hyperelongation in differentiating skeletal myocytes, suggesting a role in early skeletal muscle differentiation.
McGrath et al. (2003) studied Skeletal muscle differentiation. SLIM1 overexpression was evaluated on Myocyte elongation and differentiation. Overexpression of SLIM1 in skeletal muscle cell lines induced hyperelongation in differentiating myocytes and branching in reserve cells, both dependent on alpha5beta1-integrin signaling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: