November 18, 2004Analytical Chemistry

Labeling of Capsid Proteins and Genomic RNA of Human Rhinovirus with Two Different Fluorescent Dyes for Selective Detection by Capillary Electrophoresis

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Population

Human rhinovirus (in vitro model)

Comparison

Labeling with two different fluorescent dyes vs Native virus

Design

Preclinical

Authors

LKLeopold KremserInnsbruck Medical University MPM. PetschMedical University of Vienna DBDieter BlaasMax Perutz Labs

Discussion

Member takes

Implication

Enables dual-fluorescence CE tracking of rhinovirus; hypothesis-generating for bioanalytical methods and requires validation before broader use.

Structured PICO

Population

Human rhinovirus (in vitro model)

Intervention

Labeling with two different fluorescent dyes (RiboGreen for RNA, AMCA-S for viral protein shell)

Comparator

Native virus

Outcome

Selective detection of viral components via fluorescence in a capillary electrophoresis systemsurrogate

Double-labeling of human rhinovirus with RiboGreen and AMCA-S allows for selective detection of viral components by capillary electrophoresis while partially preserving bioaffinity and infectivity.

Cite This Study

Kremser et al. (2004) studied this question.

synapsesocial.com/papers/6a704b422163a0a01bc48427 https://doi.org/10.1021/ac048999m

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Implication

Enables dual-fluorescence CE tracking of rhinovirus; hypothesis-generating for bioanalytical methods and requires validation before broader use.

Labeling of Capsid Proteins and Genomic RNA of Human Rhinovirus with Two Different Fluorescent Dyes for Selective Detection by Capillary Electrophoresis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Labeling of Capsid Proteins and Genomic RNA of Human Rhinovirus with Two Different Fluorescent Dyes for Selective Detection by Capillary Electrophoresis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider