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February 27, 2008Magnetic Resonance in MedicineOpen Access

3D MR flow analysis in realistic rapid‐prototyping model systems of the thoracic aorta: Comparison with in vivo data and computational fluid dynamics in identical vessel geometries

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Population

Realistic rapid-prototyping model systems of the thoracic aorta based on patient-specific geometries…

Comparison

Flow-sensitive 4D MRI in a flow circuit with… vs In vivo data and computational fluid dynamics…

Design

Preclinical

Authors

CCChristian CansteinSiemens Healthcare (Germany)PCP. CachotFHNW University of Applied Sciences and ArtsAFAndreas FaustFZI Research Center for Information Technology

Discussion

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Implication

May aid controlled hemodynamic research; leaves open clinical translation pending human validation.

Structured PICO

P
Population
Realistic rapid-prototyping model systems of the thoracic aorta based on patient-specific geometries measured by contrast-enhanced MR angiography
I
Intervention
Flow-sensitive 4D MRI in a flow circuit with patient-specific pulsatile in-flow conditions
C
Comparator
In vivo data and computational fluid dynamics (CFD) simulations in identical vascular geometries
O
Outcome
Accuracy of vascular model systems evaluated by visualization of characteristic 3D flow patterns and quantitative comparisonssurrogate

Patient-specific rapid-prototyping models combined with 4D MRI can accurately simulate realistic thoracic aortic hemodynamics, offering a novel tool for cardiovascular research.

Limitations

  • Does not account for refined boundary conditions of the human circulatory system such as fluid-wall interaction

Cite This Study

Canstein et al. (2008) studied this question.

synapsesocial.com/papers/6a704bd5e71d69abee088382https://doi.org/10.1002/mrm.21331
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