Background: Periodontitis is a widespread infectious disease of the periodontium that leads to gingival inflammation and bleeding. It has become the leading cause of tooth loss in adults. Mean platelet volume (MPV), an important index of platelet activity, reflects platelet production rate and stimulation. MPV has been considered an inflammatory marker in many chronic diseases and might reflect disease activity of periodontitis. It was also known that elevated MPV is associated with cardiovascular diseases. Aims and Objectives: The aim of the present study was to investigate the relationship between MPV and chronic periodontitis and short-term effects of active periodontal treatment (APT) on MPV level. Materials and Methods: A total of 13 subjects with chronic generalized periodontitis were selected from OPD, Department of Periodontics, Kamineni Institute of Dental Sciences. All subjects received periodontal and hematological examinations at baseline and 1 week. APT was administered in all the subjects. Results: Decrease of MPV was related to the severe periodontal inflammation and the value inversed shift after active APT. Conclusion: MPV can be used as a diagnostic marker in diagnosing patients with periodontitis and also can be used as a non-pharmacological intervention in improving the platelet activity.
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