Why the study?
Does blockade of the renin-angiotensin system retard the development of atherosclerotic lesions?
Does blockade of the renin-angiotensin system retard the development of atherosclerotic lesions?
The renin-angiotensin system plays a central role in atherogenesis, making its blockade an important therapeutic target for preventing and treating atherosclerotic disease.
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Supports RAS blockade to slow atherosclerosis; confirms lesion data in models and humans yet leaves open need for randomized outcome trials.
Ferrario et al. (2004) studied this question.
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