Clonidine exhibits differential vascular effects in renal versus hindlimb beds in cats, suggesting regional differences in alpha-adrenoceptors.
Regional selectivity of clonidine versus noradrenaline in feline models; leaves open translation to human alpha-adrenoceptor pharmacology.
Cardiovascular reflexes to intravenous adrenaline and histamine and to carotid occlusion were studied in the renal vasculature, and direct effects of noradrenaline and clinidoine were compared in renal and hindlimb vascular beds in anaesthetized cats. 2. Unlike its reported effects on cardiovascular reflexes in the hindlimbs, clonidine depressed all three reflexes in the kidneys. 3. Noradrenaline caused vasoconstriction when given directly into both renal and hindlimb circulartions, but clonidine produced vasoconstriction only in the hindlimb vascular bed. 4. These results suggest that alpha-adrenoceptors in the reanl vasculature may be different from those in the hindlimbs, and that the cardiovascular reflexes in these two areas are under different control.
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Hepburn et al. (1976) studied this question.
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