Population
Dictyostelium cells (wild type and myoA- mutant strain)
Comparison
myoA mutation (lacking myosin I) vs Wild type Dictyostelium cells
Design
Preclinical
Authors
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Hypothesis-generating for myoA in amoeboid motility; validation in mammalian systems needed before cardiovascular translation.
The myoA gene plays a fundamental role in controlling the frequency of pseudopods formed on the substratum, which is necessary for normal cellular translocation and chemotaxis.
Wessels et al. (1996) studied this question.
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