June 1, 1996Molecular Biology of the CellOpen Access

Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium.

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Population

Dictyostelium (cellular slime mold)

Comparison

Overexpression of a carboxy-terminal 380-kDa… vs Expression of a central 107-kDa fragment of the…

Design

Preclinical

Authors

MKMichael P. KoonceWadsworth Center MSMontserrat SamsóVirginia Commonwealth University

Discussion

Member takes

Implication

Suggests dynein maintains microtubule organization; hypothesis-generating for cytoskeletal roles in cardiovascular cells.

Structured PICO

Population

Dictyostelium (cellular slime mold)

Intervention

Overexpression of a carboxy-terminal 380-kDa fragment of the heavy chain of cytoplasmic dynein

Comparator

Expression of a central 107-kDa fragment of the heavy chain

Outcome

Phenotype of the interphase radial microtubule array

Overexpression of the globular head of cytoplasmic dynein causes collapse of the interphase microtubule network in Dictyostelium, suggesting dynein helps maintain its spatial pattern.

Cite This Study

Koonce et al. (1996) studied this question.

synapsesocial.com/papers/6a704fe0febe604dd709180d https://doi.org/10.1091/mbc.7.6.935

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Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider