August 1, 1997Journal of Biological ChemistryOpen Access

Identification of a Microtubule-binding Domain in a Cytoplasmic Dynein Heavy Chain

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Population

Dictyostelium cytoplasmic dynein heavy chain

Comparison

Deletion and in vitro expression of the region… vs Full 10-kilobase fragment (380-kDa polypeptide)

Design

Preclinical

Authors

MKMichael P. KoonceWadsworth Center

Discussion

Member takes

Implication

Defines dynein microtubule-binding region; leaves open its role in cellular transport and motor regulation.

Structured PICO

Population

Dictyostelium cytoplasmic dynein heavy chain

Intervention

Deletion and in vitro expression of the region downstream from the fourth P-loop (amino acids 3182-3818)

Comparator

Full 10-kilobase fragment (380-kDa polypeptide)

Outcome

Microtubule binding and UV-vanadate cleavagesurrogate

This basic science study identifies a specific microtubule-binding domain in the cytoplasmic dynein heavy chain, advancing the understanding of molecular motor function.

Cite This Study

Michael P. Koonce (1997) studied this question.

synapsesocial.com/papers/6a95251f6d03747e5a2ca74b https://doi.org/10.1074/jbc.272.32.19714

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Identification of a Microtubule-binding Domain in a Cytoplasmic Dynein Heavy Chain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a Microtubule-binding Domain in a Cytoplasmic Dynein Heavy Chain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider