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May 24, 2004Journal of Medical Virology

Genetic analysis of hepatitis A virus isolates from Brazil

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Population

232 IgM anti-HAV positive serum samples collected from patients with hepatitis A living in the five…

Design

Other

Authors

VPVanessa Salete de PaulaFundação Oswaldo CruzLLLing LüTongji UniversityCNChristian NielFundação Oswaldo Cruz

Discussion

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Implication

Informs regional HAV surveillance in Brazil; leaves open whether the 2A substitution affects virulence or vaccine response.

Structured PICO

P
Population
232 IgM anti-HAV positive serum samples collected from patients with hepatitis A living in the five geographical regions of Brazil (North, Northeast, Central, South, and Southeast)
I
Intervention
Genetic analysis (sequencing of the VP1/2A junction region of the HAV genome)
O
Outcome
Genetic relatedness and genotype classification of HAV isolatessurrogate

Hepatitis A virus isolates in Brazil predominantly belong to subgenotype IA and share a characteristic geographic genetic fingerprint.

Cite This Study

Paula et al. (2004) studied this question.

synapsesocial.com/papers/6a70511e5671bbf00bc2b003https://doi.org/10.1002/jmv.20101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human enteric viruses in Coquina clams associated with a large hepatitis A outbreak2001 · 97 citations
  2. 2Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil*2001 · 81 citations
  3. 3Genetic variability of hepatitis A virus in South America reveals heterogeneity and co-circulation during epidemic outbreaks2001 · 63 citations
  4. 4Genetic analysis of hepatitis a virus outbreak in france confirms the co‐circulation of subgenotypes Ia, Ib and reveals a new genetic lineage2001 · 67 citations
  5. 5Molecular epidemiology of South African strains of hepatitis A virus: 1982–19961997 · 67 citations